Cancer Screening Based on the Analysis of Lipids Using Mass Spectrometry
The mass spectrometry (MS) based analysis of the lipids dysregulation of non-invasively collected samples of pancreatic cancer patients and healthy volunteers enables to build up the statistical models, which may be used to determine the level of probability of the patient suffering from pancreatic cancer. The whole methodology is based on accurate performance of multiple steps, including mainly the sample collection, storage, transport and processing, followed by analytical qualitative and quantitative analysis using one of three mass spectrometry based methods, followed by multivariate data analysis (MDA) of obtained absolute quantitative data. The sensitivity and specificity of this determination is very high, typically 95-100%. The method can be used for population screening of the whole population or selected population groups based on risk factors such as age, gender, body-mass-index, genetic predispositions, risk behavior, etc.
