- Introduction
- Introduction
Reason for the research
Of all cancers, pancreatic cancer is the most difficult to detect early, as there are no specific symptoms. And since early detection offers the best hope of successful treatment, it means that this cancer has the worst prognosis for survival. In addition, current cancer detection methods are limited in that they cannot be applied for large-scale screening, or they have limited sensitivity at early stages or for small tumours.
Using chemistry as possible solution
Using the existing knowledge that there are changes in the lipid metabolism of tumour cells, prof. Michal Holčapek from the Department of Analytical Chemistry at the Faculty of Chemical Technology set out to determine if chemistry could offer an effective alternative to existing screening methods. They performed several comprehensive analyses of a wide range of serum lipids by ultra-high performance supercritical fluid chromatography-mass spectrometry, which goes further than testing only one biomarker, and monitors the whole lipidome (all the lipids in given biological system).
The results
This method could not only detect pancreatic cancer, but had a throughput of over 1000 samples per month with samples being analysed within a week, and had a much greater sensitivity than current methods in use, regardless of the cancer stage. The lipid profiling could also distinguish between chronic inflammation of the pancreas (pancreatitis) and pancreatic cancer.
The way forward
Based on these results and the clear possible contribution of this method, prof Holčapek and his colleagues will be taking their research even further, determining whether it can be extended to other cancer types besides pancreatic cancer, or perhaps whether it can be used to monitor the effectiveness of cancer treatment. Their goal is to save lives: for this screening to be available in clinics and hospitals throughout the world, accessible and affordable to regular patients.
Challenges
Despite the success of their study, prof. Holčapek notes that there are still challenges before they can achieve this dream. They need funding for the very advanced and very costly equipment. They would also require the acceptance of this alternative by the medical community and the public, who could prefer to rely on traditional methods.
Persons who are interested in this study, or prospective students who could like to work on this project, are welcome to contact prof. Holčapek at Michal.Holcapek@upce.cz.
- Introduction
- Introduction
medicine (CAM). Drawing upon medical anthropology, science and technology studies and the sociology of medicine, we propose to carry out
a multi-sited ethnographic research in the Czech Republic which will, first, contribute to these three fields of study with original theoretical
insights and methodological strategies regarding disease, health and body, and second, enhance the understanding of the specificities of
CAM treatments and their interfaces with biomedicine in the contemporary Czech society. Distinctive features of the project include the focus
on 1) interfaces between biomedicine and CAM but also between different CAM approaches and practices; 2) heterogeneous materialities
and technologies as agents in the therapeutic practices; 3) technologies of the self, emerging socialities, and biosocial differentiation and
transformation taking place also beyond the medical/therapeutic settings in a strict sense.